High-entropy alloys are an exciting class of structural materials composed of a variety of primary elements. They have excellent strength, ductile combination, fracture toughness, corrosion resistance, and hydrogen embrittlement. They also have excellent stability against radiation damage and are therefore considered potential materials for advanced reactor applications. Despite the complex chemical process, high-entropy alloys can form single-phase robust solutions through a very simple lattice. For example, CrMnFeCoNi, also known as Cantor alloy, has a face-centered cubic (fcc) structure.