Desamidation of Stearic Acid Amide

(Desamidation of Stearic Acid Amide)

Fatty acid amide is the hydrolase product of fatty acid acylhydralase (FAAH). FAAH degrades stearic acid in the body, and is present in the liver. It is also found in the brain and peripheral tissues and may play a role in the transport of stearic acid to the brain, where it is metabolized into oleic acid.

The desamidation of stearic acid is the first step in the chemical conversion from a lipid to a sugar molecule. During this process, acetyl-CoA is produced, which is then used in the citric acid cycle for the reduction of NAD+and FAD to produce ATP.

A method of desamidating fatty acid amide involves reacting a vaporous liquid mixture containing at least eight carbon atoms of a fatty acid with ammonia in a reaction zone at a temperature below the boiling point of the fatty acid and at reaction temperatures for the acid. During the reaction the amides and nitriles formed are pasisned upwardly through the reaction zone, and unconverted nitriles are passed downwardly in a series of zones containing mixtures having decreasing proportions of fatty acids and increasing proportions of amides toward the bottom of the series of zones.

After the amides have been desamidated, they are converted to nitriles and ethyl-CoA in a second step. These are subsequently broken down to oleic acid and acetate in a catabolic pathway, which is used as a fuel in the cells of the organism. In addition, oleic acid is converted to triglycerides in the phospholipid pathway which can be absorbed by the cell membrane. This process is known as the phosphoinositide cascade.

(Desamidation of Stearic Acid Amide)